GisAPR

Refining atomic models against cryo-EM images without 3D volumes

← All research projects
A molecular ribbon model with a highlighted region and two structural conformations shown in purple and cream.
Molecular models connect the positions of atoms to what we see in an image.

GisAPR refines atomic models directly against 2D cryo-EM images, skipping the intermediate 3D reconstruction step. The package targets sub-tomogram-scale problems where building a high-quality 3D volume is impractical or biases the result.

Status: software in preparation.