Our lab aims to extend the reach of cryo-EM and cryo-ET to small, flexible, and transient molecular systems that remain difficult to study, enabling us to resolve their structures and states within cells.

• Seeing the unseen — How can we study small, flexible, and rare biomolecules that are hard to see? We develop methods to detect weak signals and recover their 3D structures.
• Biology inside cells — How do molecular machines work in their native environment? We aim to map their locations and structural states to uncover hidden patterns of cellular organization.
• Cryo-EM for drug discovery — Can we see how drugs bind to challenging targets? We develop tools to reveal binding pockets and molecular interactions that can guide drug design.
• Foundation models for structural biology — Can AI learn from both molecular structures and microscopy images? We aim to build models that help identify molecules and interpret images across different targets and samples.

Explore our research →

Join us — multiple openings!

The lab is actively recruiting. We welcome applications at every career stage:

• Postdoctoral fellows — strong background in cryo-EM/ET, AI, computational structural biology, or scientific computing. Please email Kexin your CV, a short research statement, and contact info for three references.
• PhD students — students interested in doing a PhD in our lab should apply through Yale’s Biological and Biomedical Sciences (BBS) program. If you are already a Yale graduate student and would like to do a rotation with us, please email Kexin directly. We are accepting rotation students!
• Master’s students — Yale master’s students interested in cryo-EM/ET methods, computational imaging, AI, or scientific software are encouraged to reach out.
• Undergraduates — Yale undergraduates looking for research experience are welcome to inquire about projects. Email Kexin directly with your CV and a brief note about your interests.
• Postgraduates — we welcome motivated applicants with a BS or MS and a strong interest in cryo-EM/ET, AI, or computational structural biology who are eager to gain hands-on research experience. Please email Kexin your CV and a brief note about your research interests and goals.