methods DiffPose Differentiable projection matching for fast pose inference in cryo-EM GisAPR Refining atomic models against cryo-EM images without 3D volumes Sub-50 kDa reconstruction with 2DTM Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching Robust target detection with 2DTM p-value A statistical metric for robust target detection in cryo-EM using high-resolution 2D template matching In situ single-particle classification Probabilistic classification of cryo-EM targets directly inside cells using 2DTM Multiscale RNA modeling with NMR chemical shifts Computational methods to determine RNA structures and conformational ensembles from NMR data software